Pradhan Prasanna
Regional Medical Research Centre (ICMR), Bhubaneswar, India.
J Vector Borne Dis. 2009 Jun;46(2):100-8.
Direct destruction and ineffective erythropoesis does not adequately explain the cause of anaemia in malaria. It is possible that there are more other mechanisms involved besides the causes described till date in malarial anaemia. The effect of NO on erythropoesis and a major haematological abnormality (microcytic/normocytic/megaloblastic picture) can significantly be observed on repeated exposure. In addition, NO can inhibit the enzyme methionine synthase so functional vit B12 deficiency state may occur which can lead to megaloblastic anaemia. This review will focus on causation of malarial anaemia and nitric oxide induced megaloblastic anaemia.
直接破坏和无效的红细胞生成并不能充分解释疟疾贫血的病因。除了迄今为止所描述的疟疾贫血病因外，可能还有更多其他机制参与其中。反复接触时，可显著观察到一氧化氮对红细胞生成的影响以及一种主要的血液学异常（小细胞/正常细胞/巨幼细胞图像）。此外，一氧化氮可抑制蛋氨酸合酶，从而可能导致功能性维生素B12缺乏状态，进而引发巨幼细胞贫血。本综述将聚焦于疟疾贫血的病因以及一氧化氮诱导的巨幼细胞贫血。
