Bensimhon D, Soyer P, Boudiaf M, Fargeaudou Y, Nemeth J, Pocard M, Idy-Peretti I, Dray X, Martin-Grivaud S, Duchat F, Hamzi L, Rymer R
Service de Radiologie Viscérale, Hôpital Lariboisière, AP-HP, GHU Nord et Université Diderot-Paris 7, 75010 Paris.
J Radiol. 2009 Apr;90(4):469-80. doi: 10.1016/s0221-0363(09)74006-5.
Gastrointestinal stromal tumors (GIST) arising from interstitial cells of Cajal, represent the first type of solid tumor, which is very sensitive to a specific molecularly targeted tyrosine kinase receptor blocker (i. e., imatinib). On CT, which is considered as the reference technique, GISTs typically present as large, well-delineated, heterogeneous and sometimes exophytic masses. In contrast with the absence of lymph node involvement, hepatic metastasis as well as mesenteric involvement can be observed. MR-enteroclysis is indicated to investigate the local extent of the disease in specific cases whereas MR imaging is used to detect hepatic metastasis. Because of a specific treatment, contrast-enhanced imaging is needed for the follow-up of treated tumors. Evaluation of tumor response to treatment is best assessed with CT which still remains the reference imaging technique whereas FDG-PET imaging is used in specific cases.
源自 Cajal 间质细胞的胃肠道间质瘤（GIST）是第一种对特定分子靶向酪氨酸激酶受体阻滞剂（即伊马替尼）非常敏感的实体瘤。在被视为参考技术的 CT 上，GIST 通常表现为大的、边界清晰的、不均匀的，有时是外生性的肿块。与无淋巴结受累相反，可以观察到肝转移以及肠系膜受累。在特定情况下，MR 小肠灌肠造影用于研究疾病的局部范围，而 MR 成像用于检测肝转移。由于采用了特定治疗，治疗后的肿瘤随访需要进行对比增强成像。肿瘤对治疗反应的评估最好用 CT 进行，CT 仍然是参考成像技术，而 FDG-PET 成像用于特定情况。
