Delgado-Baeza E, Giménez-Ribotta M, Miralles-Flores C, Nieto-Chaguaceda A, Santos Alvarez I
Laboratorio de Microcirugía Experimental, Hospital La Paz, Madrid, España.
Acta Anat (Basel). 1991;141(1):31-5. doi: 10.1159/000147095.
One of the most widespread hypotheses for chondral canal morphogenesis suggests that the canal is an extension of the perichondrium. To study the possible relation between perichondrium and chondral canal morphology, the proximal epiphyses in the tibias of 42 rats were studied from birth to their 29th day. The study was divided into three periods: from birth to the 4th day before canal appearance; from the 5th day, the moment of canal appearance, until the appearance of the secondary ossification center of the epiphysis on the 9th day; the 3rd ran from this point on the 10th day until its full development. We have also divided the canal into three regions: entrance, neck and bottom. The central portion (lumen) and canal wall were analyzed in each region. Our results show the perichondrium to be a complex structure, composed of a series of cellular layers in a biphasic extracellular matrix (eosinophil and basophil). The canal walls are lined by a layer of elongated cells. In the lumen there are many different cell types: fibroblasts, histiocytes, multinuclear giant cells and multivacuolated cells. Our study of the canal, its walls and lumen show no morphological structure that is reminiscent of the perichondrium. These results suggest that the canal is not itself a continuation of the perichondrium.
关于软骨管形态发生最广泛的假说之一认为，该管道是软骨膜的延伸。为了研究软骨膜与软骨管形态之间的可能关系，对42只大鼠胫骨近端骨骺从出生到第29天进行了研究。该研究分为三个阶段：从出生到管道出现前第4天；从第5天，即管道出现之时，到第9天骨骺次级骨化中心出现；第三个阶段从第10天这一点开始直至其完全发育。我们还将管道分为三个区域：入口、颈部和底部。对每个区域的中央部分（管腔）和管壁进行了分析。我们的结果表明，软骨膜是一种复杂的结构，由双相细胞外基质（嗜酸性和嗜碱性）中的一系列细胞层组成。管壁内衬有一层细长细胞。管腔内有许多不同类型的细胞：成纤维细胞、组织细胞、多核巨细胞和多泡细胞。我们对管道及其壁和管腔的研究未发现任何让人联想到软骨膜的形态结构。这些结果表明，该管道本身并非软骨膜的延续。
