Kreckmann Kim H, Sakr Carine J, Leonard Robin C, Dawson Barbara J
DuPont Epidemiology Program, Integrated Health Services, Newark, Delaware 19714, USA.
J Occup Environ Hyg. 2009 Sep;6(9):511-6. doi: 10.1080/15459620903025483.
Ammonium perfluorooctanoate (APFO) exposures were estimated for use in an occupational mortality study using detailed work histories of cohort members and an exposure reconstruction model developed from occupational information and serum PFO(-) data collected in 2004 as part of a cross-sectional health survey. Measured serum PFO(-) levels of the health survey participants were linked with the job title held by the individuals at the time of sampling. The median, range, and distribution of serum levels were calculated to determine the typical exposure intensity for each job title. High variability was observed in the serum levels of workers within the same job titles. In addition, working in many "APFO-use" jobs did not result in higher exposure than working in "no APFO-use" jobs. Each job title was then assigned to one of three relative APFO job exposure categories (low, medium, or high). Participants' length of time in their job was examined in relation to their serum PFO(-) level and found unlikely to contribute to misclassification of job titles within exposure categories. The mean of the serum PFO(-) measurements for each job exposure category served as the mean intensity factor. Subsequently, the job exposure categories were applied to all historical job titles of the mortality cohort based on their correspondence with job titles represented in the health survey. The resulting job exposure matrix was validated with additional historical blood data collected between 1979 through 2002 from voluntary participants in a separate biomonitoring program. The validation analyses showed general agreement between estimated and measured exposure, reflecting the within-job-title variability observed in measured serum levels used to classify job exposure.
在一项职业死亡率研究中，利用队列成员的详细工作经历以及根据职业信息和2004年作为横断面健康调查一部分收集的血清全氟辛酸（PFO⁻）数据开发的暴露重建模型，估算了全氟辛酸铵（APFO）暴露情况。将健康调查参与者的实测血清PFO⁻水平与采样时个人所担任的职位相关联。计算血清水平的中位数、范围和分布，以确定每个职位的典型暴露强度。在相同职位的工人血清水平中观察到高变异性。此外，从事许多“使用APFO”工作的工人的暴露水平并不高于从事“不使用APFO”工作的工人。然后将每个职位分配到三个相对的APFO工作暴露类别（低、中或高）之一。研究了参与者在其工作中的时长与其血清PFO⁻水平的关系，发现不太可能导致暴露类别内职位的错误分类。每个工作暴露类别的血清PFO⁻测量平均值用作平均强度因子。随后，根据与健康调查中所代表的职位的对应关系，将工作暴露类别应用于死亡率队列的所有历史职位。所得的工作暴露矩阵用1979年至2002年期间从另一个生物监测项目的自愿参与者那里收集的额外历史血液数据进行了验证。验证分析表明，估计暴露与实测暴露之间总体一致，这反映了用于分类工作暴露的实测血清水平中观察到的职位内变异性。
