Ma K C, Chang Z H, Shih H, Zhu J H, Wu J Y
Department of Pathology, School of Medicine, Shanghai Medical University, People's Republic of China.
Acta Neuropathol. 1991;82(1):72-7. doi: 10.1007/BF00310926.
This study was designed to compare the degree of reactive astrogliosis occurring around a puncture wound in the brain of normal rats and at different intervals after a similar puncture wound in rats with a portocaval anastomosis. The gliosis was evaluated by the number of astrocytes, the thickness of their processes and the intensity of the glial fibrillary acidic protein immunoreactivity. After the puncture wound in the brain of rats with a portocaval anastomosis, the gliosis varied at different intervals being: (1) decreased at 10 days, (2) markedly increased at 5 weeks and (3) significantly decreased at 8, 12, and 16 weeks. These findings suggest that 5 weeks after portocaval anastomosis, an active proliferation of the metabolically altered astrocytes occurs with heightened synthesis of glial fibrillary acidic protein in the period of adaptive compensation, the so-called compensatory 'rebound'. At 8 weeks or more after portocaval anastomosis, these altered astrocytes were considered to be in the phase of decompensation and incapable of maintaining the reactive response which occurred in normal rats. The compensatory rebound and decompensatory 'decline' illustrate the dynamic plasticity of the reactive astrogliosis.
本研究旨在比较正常大鼠脑内穿刺伤口周围以及门腔静脉吻合大鼠在类似穿刺伤口后不同时间间隔出现的反应性星形胶质细胞增生程度。通过星形胶质细胞数量、其突起厚度以及胶质纤维酸性蛋白免疫反应强度来评估胶质增生情况。在门腔静脉吻合大鼠脑内穿刺伤口后，不同时间间隔的胶质增生情况各异：（1）10天时减少；（2）5周时显著增加；（3）8周、12周和16周时显著减少。这些发现表明，门腔静脉吻合术后5周，在适应性代偿期，即所谓的代偿性“反弹”期，代谢改变的星形胶质细胞会发生活跃增殖，同时胶质纤维酸性蛋白合成增加。门腔静脉吻合术后8周及更长时间，这些改变的星形胶质细胞被认为处于失代偿阶段，无法维持正常大鼠出现的反应性反应。代偿性反弹和失代偿性“衰退”说明了反应性星形胶质细胞增生的动态可塑性。
