Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Evid Based Complement Alternat Med. 2011;2011:484590. doi: 10.1093/ecam/nep052. Epub 2011 Jun 23.
The extracts of Salacia reticulata (Salacia extract), a plant that has been used for the treatment of early diabetes, rheumatism and gonorrhea in Ayurveda, have been shown to have an anti-obesity effect and suppress hyperglycemia. In this study, the effects of Salacia extract on various symptoms of metabolic disorder were investigated and compared using these TSOD mice and non-obese TSNO mice. Body weight, food intake, plasma biochemistry, visceral and subcutaneous fat (X-ray and CT), glucose tolerance, blood pressure and pain tolerance were measured, and histopathological examination of the liver was carried out. A significant dose-dependent decline in the gain in body weight, accumulation of visceral and subcutaneous fat and an improvement of abnormal glucose tolerance, hypertension and peripheral neuropathy were noticed in TSOD mice. In addition, hepatocellular swelling, fatty degeneration of hepatocytes, inflammatory cell infiltration and single-cell necrosis were observed on histopathological examination of the liver in TSOD mice. Salacia extract markedly improved these symptoms upon treatment. Based on the above results, it is concluded that Salacia extract has remarkable potential to prevent obesity and associated metabolic disorders including the development of metabolic syndrome.
藤三七提取物（藤三七提取物），一种用于治疗早期糖尿病、风湿病和古印度医学淋病的植物，已被证明具有抗肥胖作用和抑制高血糖作用。在这项研究中，使用这些 TSOD 小鼠和非肥胖 TSNO 小鼠研究和比较了藤三七提取物对代谢紊乱各种症状的影响。测量了体重、食物摄入量、血浆生化、内脏和皮下脂肪（X 射线和 CT）、葡萄糖耐量、血压和疼痛耐受，并对肝脏进行了组织病理学检查。在 TSOD 小鼠中，体重增加、内脏和皮下脂肪积累以及异常葡萄糖耐量、高血压和周围神经病的改善均呈显著的剂量依赖性下降。此外，在 TSOD 小鼠的肝脏组织病理学检查中观察到肝细胞肿胀、肝细胞脂肪变性、炎性细胞浸润和单个细胞坏死。藤三七提取物治疗后明显改善了这些症状。基于上述结果，可以得出结论，藤三七提取物具有预防肥胖和相关代谢紊乱（包括代谢综合征的发展）的显著潜力。
