Dong Ai-Sheng, Tian Jian-Ming, Lu Jian-Ping, Zuo Chang-Jing, Wang Li, Wang Jian
Department of Nuclear Medicine, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2009 Apr;31(2):151-4.
To investigate the value of in vivo proton magnetic resonance spectroscopy (1H MRS) in the assessment of hepatocellular carcinoma (HCC) and cholangiocarcinoma.
1H MRS was performed in normal volunteers and in patients with pathologically confirmed HCC and cholangiocarcinomas using a whole-body 1.5-T scanner. The choline-to-lipid ratios were measured by dividing the peak area of choline at 3.2 ppm and lipid at 1.3 ppm.
The ratio of choline-to-lipid for normal liver, cholangiocarcinomas, and HCC were 0.07 +/- 0.04, 0.11 +/- 0.06, and 0.52 +/- 0.15, respectively. The ratio of choline-to-lipid was significantly higher in HCC compared than those in cholangiocarcinomas or normal livers (P < 0.05). However, it was not significantly different between cholangiocarcinomas and normal livers (P > 0.05).
In vivo 1H MRS can reflect the pathological changes of HCC and cholangiocarcinomas at metabolic level and thus is useful in the diagnosis of these two cancers.
探讨活体质子磁共振波谱（1H MRS）在评估肝细胞癌（HCC）和胆管癌中的价值。
使用全身1.5-T扫描仪对正常志愿者以及病理确诊的HCC和胆管癌患者进行1H MRS检查。通过将3.2 ppm处胆碱的峰面积除以1.3 ppm处脂质的峰面积来测量胆碱与脂质的比率。
正常肝脏、胆管癌和HCC的胆碱与脂质比率分别为0.07±0.04、0.11±0.06和0.52±0.15。与胆管癌或正常肝脏相比，HCC中的胆碱与脂质比率显著更高（P<0.05）。然而，胆管癌与正常肝脏之间无显著差异（P>0.05）。
活体1H MRS可在代谢水平反映HCC和胆管癌的病理变化，因此对这两种癌症的诊断有用。
