Nowier Shahira Riad, Eldeen Nermin Salah, Farid Mona M, Rasol Hoiyda A Abdel, Mekhemer Salma M
Genetics Department, Research Institute of Ophthalmology, Cairo University, Egypt.
Bratisl Lek Listy. 2009;110(4):258-62.
Celiac disease (CD) is a common genetically transmitted immune mediated disease.
Seventy three type 1 DM patients attending the Diabetes, Metabolic and Endocrinology outpatient clinic were recruited in the study. Thorough history taking and medical examination were done. They were screened for the prevalence of celiac disease by ELISA for coeliac disease antibodies against tTG. Anti-thyroglobulin antibodies, antithyroidperoxidase antibodies were analysed to estimate the prevalence of autoimmune thyroid disease.
Four out of seventy three (5.48%) type 1 diabetic children were seropositive for anti-tTG antibodies. They had symptoms of celiac disease such as chronic diarrhea (5.48%), recurrent abdominal pain (2.7%) and short stature (5.48%). Six patients were diagnosed with autoimmune thyroid diseases as they were seropositive for antithyroglobulin antibodies and/or antithyroidperoxidase antibodies. None of them proved to be positive for anti-tTG antibodies.
The prevalence of CD among Type 1 DM patients by using tissue transglutaminase antibodies ELISA was (5.48%) which supports the current practice of screening for celiac disease. Patients with autoimmune thyroid disease were negative for anti-tTG antibodies. HbA1c levels were adversely affected by malabsorption related to celiac disease in seropositive patients (Tab. 5, Ref. 27). Full Text (Free, PDF) www.bmj.sk.
乳糜泻（CD）是一种常见的遗传性免疫介导疾病。
本研究招募了73名在糖尿病、代谢和内分泌门诊就诊的1型糖尿病患者。进行了详细的病史采集和体格检查。通过酶联免疫吸附测定（ELISA）检测抗组织转谷氨酰胺酶（tTG）抗体，以筛查乳糜泻的患病率。分析抗甲状腺球蛋白抗体、抗甲状腺过氧化物酶抗体，以评估自身免疫性甲状腺疾病的患病率。
73名1型糖尿病儿童中有4名（5.48%）抗tTG抗体血清学阳性。他们有乳糜泻的症状，如慢性腹泻（5.48%）、反复腹痛（2.7%）和身材矮小（5.48%）。6名患者因抗甲状腺球蛋白抗体和/或抗甲状腺过氧化物酶抗体血清学阳性而被诊断为自身免疫性甲状腺疾病。他们中没有一人抗tTG抗体检测呈阳性。
通过组织转谷氨酰胺酶抗体ELISA检测，1型糖尿病患者中乳糜泻的患病率为5.48%，这支持了目前筛查乳糜泻的做法。自身免疫性甲状腺疾病患者抗tTG抗体检测为阴性。血清学阳性患者中，与乳糜泻相关的吸收不良对糖化血红蛋白（HbA1c）水平有不利影响（表5，参考文献27）。全文（免费，PDF）www.bmj.sk 。
