Narendra N, Vishwanatha T M, Sudarshan N S, Sureshbabu Vommina V
Peptide Research Laboratory, Department of Studies in Chemistry, Central College Campus, Bangalore University, Dr. B R Ambedkar Veedhi, Bangalore-560 001, India.
Protein Pept Lett. 2009;16(9):1029-35. doi: 10.2174/092986609789055403. Epub 2009 Sep 1.
We report a one pot synthesis of Fmoc amino acid derived 4-amino-thiazole derivatives and thiazole linked N-orthogonally protected dipeptidomimetics by the condensation of N(alpha)-Fmoc alpha-halomethylketones with thiourea and Boc/Z-alpha-amino acid thioamides via modified Hantzch protocol. Side chain modified Fmoc amino acids containing 4-amino thiazole moiety have also been synthesized following the similar protocol.
