Li Hai-feng, Zou Yan, Xia Zhe-zhi, Gao Feng, Feng Jian-hua, Yang Cui-wei
The Children's Hospital Zhejiang University School of Medicine, Hangzhou, China.
Acta Paediatr. 2009 Sep;98(9):1521-5. doi: 10.1111/j.1651-2227.2009.01349.x. Epub 2009 Jun 8.
To explore the mechanism of topiramate-induced weight loss in epilepsy children by monitoring metabolism indices.
Children with epilepsy were treated with topiramate at their first clinical visit. Metabolism indices including body mass index (BMI) and its SD scores, leptin, adiponectin, leptin/adiponectin (L/A), lipid profile-insulin and Homeostasis Model Assessments (HOMA) index were collected before and after treatment.
Topiramate treatment significantly reduced L/A (t = 2.156, p = 0.031), and markedly increased the serum level of adiponectin (t = 3.124, p = 0.002). Moreover, there were no relationships between the metabolism indices and dosages of topiramate (p > 0.05).
Our studies find that topiramate treatment in epilepsy children increases energy metabolism, resulting in weight loss. It has been demonstrated that adiponectin play a significant role in metabolic regulations.
通过监测代谢指标探讨托吡酯诱导癫痫儿童体重减轻的机制。
癫痫患儿在首次临床就诊时接受托吡酯治疗。收集治疗前后的代谢指标，包括体重指数（BMI）及其标准差评分、瘦素、脂联素、瘦素/脂联素（L/A）、血脂-胰岛素和稳态模型评估（HOMA）指数。
托吡酯治疗显著降低L/A（t = 2.156，p = 0.031），并显著提高脂联素血清水平（t = 3.124，p = 0.002）。此外，代谢指标与托吡酯剂量之间无相关性（p > 0.05）。
我们的研究发现，托吡酯治疗癫痫儿童可增加能量代谢，导致体重减轻。已证明脂联素在代谢调节中起重要作用。
