中国人群中一种新型HLA-DRB1*12等位基因DRB1*1218的鉴定。
Identification of a novel HLA-DRB1*12 allele, DRB1*1218, in Chinese population.
作者信息
Gao S-Q, Deng Z-H, Xu Y-P
机构信息
Shenzhen Institute of Transfusion Medicine, Shenzhen Blood Center, Shenzhen, China.
出版信息
Tissue Antigens. 2009 Sep;74(3):265-7. doi: 10.1111/j.1399-0039.2009.01294.x. Epub 2009 Jun 10.
Abstract
Here, we report the identification of a novel human leukocyte antigen-DRB112 variant, DRB11218 allele, in a Chinese Han individual. The novel DRB112 variant allele differed from the closest allele DRB1120201 by nucleotide 262 G>C (codon 59 GAG>CAG) missense mutation in exon 2, which resulted in an amino acid substitution of Glu>Gln.
摘要
在此，我们报告在中国汉族个体中鉴定出一种新型人类白细胞抗原-DRB112变体，即DRB11218等位基因。该新型DRB112变体等位基因与最接近的等位基因DRB1120201在外显子2中存在核苷酸262 G>C（密码子59 GAG>CAG）错义突变，这导致了氨基酸替换Glu>Gln。
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