Watts Richard A, Scott David G I
School of Medicine, Health Policy and Practice, University of East Anglia, Norwich, UK.
Best Pract Res Clin Rheumatol. 2009 Jun;23(3):429-43. doi: 10.1016/j.berh.2008.12.004.
The systemic vasculitides are a group of multisystem diseases characterized by inflammation of blood vessels. The aetiopathogenesis is unknown, and therefore nomenclature and classification are often descriptive and based on pathological features. Generally agreed classification schemes are vital to enable large multicentre or multinational clinical trials to be undertaken. An algorithm has recently been developed to harmonize use of the American College of Rheumatology (ACR) 1990 criteria and the Chapel Hill Consensus Conference definitions. Despite this, a revision of the classification criteria is still needed, and diagnostic criteria need to be developed ab initio. The very complexity of the diseases makes accurate objective assessment critical, especially for the conduct of clinical trials. Several standardized assessment tools for both disease activity and damage have been developed over the past two decades and are now widely used in both clinical trials and routine practice. A second generation of tools is now under development.
系统性血管炎是一组以血管炎症为特征的多系统疾病。其病因发病机制尚不清楚，因此命名和分类通常是描述性的，基于病理特征。普遍认可的分类方案对于开展大型多中心或跨国临床试验至关重要。最近开发了一种算法，以协调美国风湿病学会（ACR）1990年标准和查珀尔希尔共识会议定义的使用。尽管如此，分类标准仍需修订，并且需要从头开始制定诊断标准。这些疾病的复杂性使得准确的客观评估至关重要，尤其是对于临床试验的开展。在过去二十年中，已经开发了几种用于疾病活动和损伤的标准化评估工具，现在广泛应用于临床试验和常规实践。目前正在开发第二代工具。
