Rose Stephen L
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA.
Int J Gynecol Cancer. 2009 May;19(4):564-6. doi: 10.1111/IGC.0b013e3181a12ed2.
The literature is replete with reports of the paradoxical role of Notch signaling in human cancer. Notch appears to act as both an oncogene and a tumor suppressor gene depending on the cellular context. This review focuses on the nascent knowledge of Notch signaling in ovarian cancer. Despite advances in chemotherapy and radical surgery, ovarian cancer remains the most deadly gynecologic malignancy. Therapeutic improvements are necessary to enhance outcomes of patients with ovarian cancer. I will review the evidence for Notch activation in ovarian cancer and potential strategies for Notch inactivation as targeted treatment of ovarian cancer.
文献中充斥着关于Notch信号通路在人类癌症中矛盾作用的报道。根据细胞环境的不同，Notch似乎既作为癌基因又作为肿瘤抑制基因发挥作用。本综述聚焦于卵巢癌中Notch信号通路的最新知识。尽管化疗和根治性手术取得了进展，但卵巢癌仍然是最致命的妇科恶性肿瘤。有必要进行治疗改进以提高卵巢癌患者的治疗效果。我将综述卵巢癌中Notch激活的证据以及将Notch失活作为卵巢癌靶向治疗的潜在策略。
