Serebrov V Yu, Kuzmenko D I, Burov P G, Novitsky S V
Department of Biochemistry and Molecular Biology, Siberian State Medical University, Russian Ministry of Health, Tomsk, Russia.
Bull Exp Biol Med. 2008 Dec;146(6):726-9. doi: 10.1007/s10517-009-0387-4.
Activities of sphingomyelinase and ceramidase decreased in the liver in chronic toxic hepatitis and the balance between the levels of proapoptotic ceramide and antiapoptotic sphyngosine-1-phosphate shifts towards the latter substance. Pronounced changes in the qualitative and quantitative composition of fatty acids in the sphingomyelin cycle effector molecules were revealed.
在慢性中毒性肝炎中，肝脏中的鞘磷脂酶和神经酰胺酶活性降低，促凋亡神经酰胺和抗凋亡鞘氨醇-1-磷酸水平之间的平衡向后者物质倾斜。研究发现，鞘磷脂循环效应分子中脂肪酸的定性和定量组成发生了显著变化。
