Mievis C, Jansen N, Schleich F, Gennigens C, Rorive A, Jérusalem G, Fillet G, Sautois B
Service de Radiothérapie, CHU de Liège, Belgique.
Rev Med Liege. 2009 Apr;64(4):179-81.
Radiation recall dermatitis is an inflammatory skin reaction occurring in a previously irradiated field following the delivery of a promoting agent. It has been described after a number of antineoplastic agents such as gemcitabine, taxanes, anthracyclines. We report the case of a 50-year-old man with metastatic prostate cancer who developed two consecutive radiation recall dermatitis episodes triggered by oral cyclophosphamide. They occurred 4 to 5 weeks after palliative radiotherapy on bone metastasis. Spontaneous resolution was observed within 6 weeks after discontinuation of cyclophosphamide and with local supportive care. To our knowledge this is the first reported case of radiation recall dermatitis after oral cyclophosphamide.
放射性回忆性皮炎是一种炎症性皮肤反应，发生在先前接受过放疗的部位，在给予促发剂后出现。在多种抗肿瘤药物如吉西他滨、紫杉烷类、蒽环类药物之后都有相关报道。我们报告一例50岁转移性前列腺癌男性患者，其因口服环磷酰胺引发了连续两次放射性回忆性皮炎发作。发作发生在骨转移姑息性放疗后4至5周。停用环磷酰胺并给予局部支持治疗后，6周内皮疹自发消退。据我们所知，这是口服环磷酰胺后放射性回忆性皮炎的首例报道病例。
