Wiśniewski Marek, Łukasik-Głebocka Magdalena, Anand Jacek Sein
Clinic of Internal Diseases and Acute Poisonings, Medical University of Gdańsk, Gdańsk, Poland.
Clin Toxicol (Phila). 2009 Apr;47(4):317-20. doi: 10.1080/15563650601117954.
The clinical manifestations of acute topiramate toxicity are described.
Seven cases of acute and acute-on-chronic topiramate toxicity observed in two clinical units of Polish Poison Control Centers in 2004-2005 were analyzed.
The patients were 4 women and 2 men aged between 16 and 38 (mean 21.0 +/- 8.4) years. The doses of topiramate ranged from 10.7 to 218 mg/kg. The most frequent symptom was somnolence (66.7%) and, vertigo, agitation, and mydriasis were less common (33.4%). One patient who was not previously treated with topiramate experienced three secondarily generalized tonic-clonic seizures. Metabolic acidosis, lasting for 3-7 days, was observed in four cases, and did not influence the outcome.
The clinical manifestations of acute poisonings with topiramate ranged from asymptomatic to severe, but no distant sequelae or fatalities were observed. The course of acute poisoning seems to be more severe in patients who were not previously treated with topiramate.
描述了托吡酯急性中毒的临床表现。
分析了2004年至2005年在波兰中毒控制中心两个临床科室观察到的7例急性及急性加慢性托吡酯中毒病例。
患者为4名女性和2名男性，年龄在16至38岁之间（平均21.0 +/- 8.4岁）。托吡酯剂量范围为10.7至218毫克/千克。最常见的症状是嗜睡（66.7%），眩晕、激动和瞳孔散大则较少见（33.4%）。1例既往未接受过托吡酯治疗的患者发生了3次继发性全身强直阵挛性发作。4例患者出现持续3至7天的代谢性酸中毒，但未影响预后。
托吡酯急性中毒的临床表现从无症状到严重不等，但未观察到远期后遗症或死亡病例。既往未接受过托吡酯治疗的患者急性中毒病程似乎更严重。
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