Divaris D X, Ling F C, Prentice R S
Department of Pathology, Queen's University, Kingston, Ontario, Canada.
Am J Dermatopathol. 1991 Oct;13(5):481-7.
Congenital self-healing histiocytosis (CSHH) is a rare primary skin disorder. Of the two cases in newborn infants reported here, one had numerous widespread lesions while the other had a solitary ulcerating scalp nodule. Both neonates were otherwise healthy; neither exhibited either systemic involvement or involvement of mucous membranes. The findings drawn from the skin biopsies, including histology, S-100 positivity in the majority of the cells, and the presence of Birbeck granules, were indistinguishable from those described in infantile Letterer-Siwe disease (histiocytosis X). However, the benign clinical course, with rapid regression of the nodules in both cases, was diagnostic of CSHH.
先天性自愈性组织细胞增多症（CSHH）是一种罕见的原发性皮肤疾病。在此报告的两例新生儿病例中，一例有大量广泛分布的皮损，另一例有一个孤立的溃疡性头皮结节。两名新生儿其他方面均健康；均未表现出系统性受累或黏膜受累。皮肤活检结果，包括组织学、大多数细胞S-100阳性以及存在伯贝克颗粒，与婴儿勒-雪病（组织细胞增多症X）中描述的结果无法区分。然而，两例病例中结节均迅速消退的良性临床过程可诊断为CSHH。
