Boissonnas Alexandre, Scholer-Dahire Alix, Fetler Luc, Amigorena Sebastian
Institut National de la Santé et de la Recherche Médicale U653, Immunité et Cancer, Pavillon Pasteur, Institut Curie, 26 rue d'Ulm, Paris Cedex 05, France.
Curr Top Microbiol Immunol. 2009;334:265-87. doi: 10.1007/978-3-540-93864-4_11.
The actual contribution of T lymphocytes to protection against tumors is still unclear. In vitro imaging experiments show that tumor specific cytotoxic T lymphocytes (CTLs) are competent to kill target cells by conventional cytotoxic pathways. The emergence of multiphoton imaging in the past decade now allows real time in vivo imaging of CTLs. New insights are available on the behavior of antitumor T cells during the priming phase, during their traffic within the tumor tissue, and on their interactions with tumor cells during the effector phase. Recent reports suggest that direct killing of tumor cells by CTLs is a slow process, suggesting that the ratio of effector to target cells is determinant, or that additional cytotoxic contribution by other cell types is required to induce efficient tumor rejection. This review will focus on the publications that have imaged antitumor immune responses dynamically and discuss how this new information contributes to understand the implication of CTLs in tumor rejection.
T淋巴细胞对肿瘤保护的实际贡献仍不明确。体外成像实验表明，肿瘤特异性细胞毒性T淋巴细胞（CTL）能够通过传统的细胞毒性途径杀伤靶细胞。过去十年中多光子成像技术的出现，使得对CTL进行实时体内成像成为可能。关于抗肿瘤T细胞在启动阶段、在肿瘤组织内游走过程中以及效应阶段与肿瘤细胞相互作用的行为，现在有了新的见解。最近的报告表明，CTL直接杀伤肿瘤细胞是一个缓慢的过程，这表明效应细胞与靶细胞的比例是决定性因素，或者需要其他细胞类型的额外细胞毒性作用来诱导有效的肿瘤排斥反应。本综述将聚焦于动态成像抗肿瘤免疫反应的相关出版物，并讨论这些新信息如何有助于理解CTL在肿瘤排斥中的作用。
