MRC Centre for Neurodegeneration Research, King's College London, Institute of Psychiatry, UK.
Neurobiol Aging. 2011 May;32(5):966-7. doi: 10.1016/j.neurobiolaging.2009.05.014. Epub 2009 Jun 13.
We have attempted to replicate a recently reported association of polymorphism rs10260404, in the Dipeptidyl-peptidase 6 gene (DPP6), with susceptibility to amyotrophic lateral sclerosis (ALS) in a large independent Italian cohort of 904 cases and 1036 controls. Minor allele frequency was 0.38 in cases and 0.39 in controls and no evidence of association with ALS was observed (P=0.638). Our negative results agree with those recently reported in additional Polish and Italian cohorts.
我们试图在一个由 904 例病例和 1036 例对照组成的大型独立意大利队列中复制最近报道的二肽基肽酶 6 基因 (DPP6) 多态性 rs10260404 与肌萎缩侧索硬化症 (ALS) 易感性的关联。在病例组和对照组中，次要等位基因频率分别为 0.38 和 0.39，未观察到与 ALS 相关的证据 (P=0.638)。我们的阴性结果与最近在其他波兰和意大利队列中报道的结果一致。
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