Daoud Hussein, Valdmanis Paul N, Dion Patrick A, Rouleau Guy A
Centre of Excellence in Neuromics, Université de Montréal, Montreal, Quebec, Canada.
Amyotroph Lateral Scler. 2010 Aug;11(4):389-91. doi: 10.3109/17482960903358857.
DPP6 and FGGY genes have been recently associated with an increased susceptibility for sporadic amyotrophic lateral sclerosis. Here, we evaluated the role of these genes in ALS pathogenesis by undertaking a sequence analysis of a cohort of 190 ALS patients from France and Quebec. We did not observe any evidence that mutations in DPP6 and FGGY genes are involved in ALS. Our data indicate that mutations in these genes are unlikely to be a common cause of ALS in the French and French Canadian populations.
DPP6和FGGY基因最近被认为与散发性肌萎缩侧索硬化症的易感性增加有关。在此，我们通过对来自法国和魁北克的190例肌萎缩侧索硬化症患者队列进行序列分析，评估了这些基因在肌萎缩侧索硬化症发病机制中的作用。我们没有观察到任何证据表明DPP6和FGGY基因的突变与肌萎缩侧索硬化症有关。我们的数据表明，在法国人和法裔加拿大人中，这些基因的突变不太可能是肌萎缩侧索硬化症的常见病因。
