Altmeyer Mary D, Anderson Lisa L, Wang Alun R
Department of Dermatology, Tulane University Health Sciences Center, New Orleans, LA 70112-2699, USA.
J Cosmet Dermatol. 2009 Jun;8(2):92-7. doi: 10.1111/j.1473-2165.2009.00436.x.
The use of liquid injectable silicone for soft tissue augmentation is a controversial practice within the medical community. Injectable silicone has been illegally obtained, adulterated, and abused by nonmedical practitioners for the last five decades. Injection of silicone can result in catastrophic consequences including death, when grossly abused. Opponents of this practice cite the many serious adverse events that have occurred with its use both legally and illegally. Proponents argue that employment of a stringent regimen of use as well as a highly purified medical grade product allow for a safe utilization of the material. Both sides agree that this practice calls for a high degree of knowledge and technical skill. A continued evaluation of the long-term safety of this material is necessary before a consensus can be reached. Herein, we report a case of illegal administration of injectable silicone resulting in product migration accompanied by a granulomatous response. Further, the literature that both supports and refutes the practice of silicone injection is reviewed.
使用液体注射用硅酮进行软组织填充在医学界是一种存在争议的做法。在过去五十年里，注射用硅酮被非医疗从业者非法获取、掺假并滥用。如果严重滥用，注射硅酮可能会导致包括死亡在内的灾难性后果。这种做法的反对者列举了其合法和非法使用时发生的许多严重不良事件。支持者则认为，采用严格的使用方案以及高纯度的医用级产品可以安全地使用这种材料。双方都认同这种做法需要高度的知识和技术技能。在达成共识之前，有必要持续评估这种材料的长期安全性。在此，我们报告一例注射用硅酮非法注射导致产品迁移并伴有肉芽肿反应的病例。此外，还对支持和反驳硅酮注射做法的文献进行了综述。
