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新型凝血剂(安卡纤维蛋白胶)治疗伴有抑制剂的血友病开放性出血。

New coagulant agent (ankaferd blood stopper) for open hemorrhages in hemophilia with inhibitor.

机构信息

Department of Pediatric Hematology, Van, Turkey.

出版信息

Clin Appl Thromb Hemost. 2010 Dec;16(6):705-7. doi: 10.1177/1076029609337313. Epub 2009 Jun 14.

DOI:10.1177/1076029609337313
PMID:19528064
Abstract

The treatment of hemophilia A patients with inhibitor could be very expensive. Ankaferd blood stopper (ABS) is a unique folkloric medicinal plant extract, which has historically been used in Turkish traditional medicine as a hemostatic agent. In this article, a 16-year-old boy was presented with uncontrolled bleeding, despite the treatment of factor VIII, rVIIa, factor VIII inhibitor bypass activity (FEIBA), cyclophosphamide, and prednisolone at circumcision site that resolved with ABS in minutes. Our patient with hemophilia A and inhibitor is the first clinical pediatric case.

摘要

治疗有抑制剂的 A 型血友病患者可能非常昂贵。安卡弗德血液止血剂(ABS)是一种独特的民俗药用植物提取物,在土耳其传统医学中一直被用作止血剂。在本文中,一名 16 岁男孩在接受了因子 VIII、rVIIa、因子 VIII 抑制剂旁路活性(FEIBA)、环磷酰胺和泼尼松龙治疗后,仍在割礼部位出现无法控制的出血,但使用 ABS 后几分钟内出血就停止了。我们的 A 型血友病伴抑制剂患者是首例临床儿科病例。

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引用本文的文献

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Indian J Hematol Blood Transfus. 2016 Sep;32(3):347-55. doi: 10.1007/s12288-015-0562-x. Epub 2015 Jun 18.
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The Effectiveness of a New Hemostatic Agent (Ankaferd Blood Stopper) for the Control of Bleeding following Tooth Extraction in Hemophilia: A Controlled Clinical Trial.新型止血剂(安可血凝酶)控制血友病患者拔牙后出血的有效性:一项对照临床试验。
Turk J Haematol. 2013 Mar;30(1):19-24. doi: 10.4274/tjh.2012.0036. Epub 2013 Mar 5.
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The Dual Diverse Dynamic Reversible Effects of Ankaferd Blood Stopper on EPCR and PAI-1 Inside Vascular Endothelial Cells With and Without LPS Challenge.
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Turk J Haematol. 2012 Dec;29(4):361-6. doi: 10.5152/tjh.2011.41. Epub 2012 Dec 5.