InterMap3D：预测和可视化共同进化的蛋白质残基。
InterMap3D: predicting and visualizing co-evolving protein residues.
机构信息
Center for Biological Sequence Analysis, Technical University of Denmark, DK-2800 Lyngby, Denmark.
出版信息
Bioinformatics. 2009 Aug 1;25(15):1963-5. doi: 10.1093/bioinformatics/btp335. Epub 2009 Jun 15.
SUMMARY
InterMap3D predicts co-evolving protein residues and plots them on the 3D protein structure. Starting with a single protein sequence, InterMap3D automatically finds a set of homologous sequences, generates an alignment and fetches the most similar 3D structure from the Protein Data Bank (PDB). It can also accept a user-generated alignment. Based on the alignment, co-evolving residues are then predicted using three different methods: Row and Column Weighing of Mutual Information, Mutual Information/Entropy and Dependency. Finally, InterMap3D generates high-quality images of the protein with the predicted co-evolving residues highlighted.
AVAILABILITY
摘要
InterMap3D 预测共进化的蛋白质残基，并将其绘制在 3D 蛋白质结构上。从单个蛋白质序列开始，InterMap3D 自动找到一组同源序列，生成比对，并从蛋白质数据库（PDB）中获取最相似的 3D 结构。它还可以接受用户生成的比对。基于比对，然后使用三种不同的方法预测共进化残基：互信息的行列加权、互信息/熵和依赖性。最后，InterMap3D 生成带有预测共进化残基突出显示的蛋白质高质量图像。
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