Markham R B, Stashak P W, Prescott B, Amsbaugh D F, Baker P J
J Immunol. 1977 Sep;119(3):1159-62.
Amplifier T cells responsible for enhancement of the antibody response to type III pneumococcal polysaccharide have been shown to be resistant to the effects of antilymphocyte serum (ALS) given at the time of immunization, a treatment that eliminates suppressor T cell activity. The resistance of amplifier T cells to ALS can be attributed to the fact that their activity develops after that of suppressor T cells. ALS given 1 or 2 days after immunization does abrogate amplifier T cell activity, independent of the mode by which that activity is elicited. The data emphasize the importance of kinetic considerations in understanding the effects produced by immunologically active agents such as ALS.
已证明，负责增强对III型肺炎球菌多糖抗体反应的放大T细胞对免疫时给予的抗淋巴细胞血清（ALS）的作用具有抗性，而这种处理会消除抑制性T细胞活性。放大T细胞对ALS的抗性可归因于其活性在抑制性T细胞之后发展这一事实。免疫后1或2天给予ALS确实会消除放大T细胞活性，而与引发该活性的方式无关。这些数据强调了动力学考量在理解诸如ALS等免疫活性剂所产生的效应方面的重要性。
