Halkos Michael E, Puskas John D
Clinical Research Unit, Division of Cardiothoracic Surgery, Emory University School of Medicine, 550 Peachtree Street, Atlanta, GA 30308, USA.
Curr Opin Cardiol. 2009 Mar;24(2):136-41. doi: 10.1097/HCO.0b013e328324e698.
Four different bileaflet mechanical prostheses are currently utilized for valve replacement in the United States. We reviewed the different designs, hemodynamic features, and long-term outcomes of each of these prostheses.
Bileaflet mechanical valves provide excellent long-term durability and overall superb hemodynamic performance. Subtle design modifications have maximized the effective orifice area per given valve size, which minimizes outflow gradients in smaller sizes. These newer-generation valves require a lower level of anticoagulation compared with older models. Compared with bioprosthetic valves, freedom from structural valve deterioration and reoperation is significantly better with bileaflet mechanical valves. However, hemorrhagic and thromboembolic complications related to anticoagulation remain a major limitation.
Bileaflet mechanical valves are a valuable option for patients undergoing valve replacement surgery. All of the bileaflet designs provide good hemodynamic performance with long-term durability. However, some designs may provide better hemodynamic profiles in smaller valve sizes. Furthermore, newer models may have a more favorable thromboembolic profile. Nonetheless, the risk of anticoagulant-related complications with mechanical valves must be weighed against the risks of structural deterioration and reoperation of bioprostheses. Ultimately, the choice of prosthesis should be made after careful discussion with the patient, referring cardiologist, and cardiac surgeon.
目前在美国有四种不同的双叶机械瓣膜用于瓣膜置换。我们回顾了这些瓣膜各自的不同设计、血流动力学特征及长期预后。
双叶机械瓣膜具有出色的长期耐用性和总体卓越的血流动力学性能。细微的设计改进使给定瓣膜尺寸下的有效瓣口面积最大化,从而将较小尺寸瓣膜的流出道梯度降至最低。与旧型号相比,这些新一代瓣膜所需的抗凝水平较低。与生物瓣膜相比,双叶机械瓣膜在免于结构性瓣膜退变和再次手术方面表现明显更佳。然而,与抗凝相关的出血和血栓栓塞并发症仍然是一个主要限制因素。
双叶机械瓣膜对于接受瓣膜置换手术患者而言是一个有价值的选择。所有双叶设计均具有良好的血流动力学性能和长期耐用性。然而,某些设计在较小瓣膜尺寸下可能具有更好的血流动力学表现。此外,新型号可能具有更有利的血栓栓塞情况。尽管如此,必须权衡机械瓣膜抗凝相关并发症的风险与生物瓣膜结构性退变和再次手术的风险。最终,应在与患者、转诊心脏病专家及心脏外科医生仔细讨论后做出瓣膜选择。