Uldry P Y, Jenny M
Schweiz Med Wochenschr. 1977 Jun 18;107(24):845-53.
In the light of seven cases of adrenal hypercorticalism associated with tumoral secretion of ACTH, the syndrome of inappropriate ACTH secretion is reviewed. This entity, which is related primarily to anaplastic bronchial carcinoma is characterized by paucity of clinical signs of hypercorticalism, rapidity of evolution and typical biological modifications. Other important criteria are hypokalemic alkalosis, high plasma levels of ACTH and 17-OHCS and failure of dexamethasome to suppress endogenous steroid secretion. However, the diagnosis can be proven only by extraction of a significant quantity of tumoral ACTH.
根据7例与促肾上腺皮质激素（ACTH）肿瘤分泌相关的肾上腺皮质功能亢进病例，对不适当ACTH分泌综合征进行了综述。该病症主要与间变性支气管癌有关，其特征为皮质功能亢进的临床体征较少、病情进展迅速以及典型的生物学改变。其他重要标准包括低钾性碱中毒、血浆ACTH和17-羟皮质类固醇（17-OHCS）水平升高以及地塞米松不能抑制内源性类固醇分泌。然而，只有通过提取大量肿瘤性ACTH才能证实诊断。
