色氨酸-两性霉素B缀合物的合成与研究。

Synthesis and investigation of tryptophan-amphotericin B conjugates.

作者信息

Zumbuehl Andreas, Stano Pasquale, Sohrmann Marc, Dietiker Rolf, Peter Mathias, Carreira Erick M

机构信息

Department of Chemistry and Applied Biosciences, ETH Zürich, Hönggerberg, Zürich, Switzerland.

出版信息

Chembiochem. 2009 Jul 6;10(10):1617-20. doi: 10.1002/cbic.200900096.

DOI:10.1002/cbic.200900096

PMID:19533712

Abstract

Anchors aweigh! The synthesis of tryptophan-amphotericin B conjugates (see figure) is described. The membrane-anchoring effect of tryptophane was thus combined with the pore-formation effect of amphotericin B leading to high channel activity in sterol-free liposomes.

摘要

起锚！本文描述了色氨酸 - 两性霉素B缀合物的合成（见图）。色氨酸的膜锚定作用与两性霉素B的成孔作用相结合，从而在无甾醇脂质体中产生高通道活性。