一种新型生物共轭策略：两性霉素B的合成与初步评估。
A novel strategy for bioconjugation: synthesis and preliminary evaluation with amphotericin B.
作者信息
Zumbuehl Andreas, Stano Pasquale, Sohrmann Marc, Peter Mathias, Walde Peter, Carreira Erick M
机构信息
Laboratorium für Organische Chemie, ETH Hönggerberg, 8093, Zürich, Switzerland.
出版信息
Org Biomol Chem. 2007 May 7;5(9):1339-42. doi: 10.1039/b701953j. Epub 2007 Mar 23.
DOI:10.1039/b701953j
PMID:17464400
Abstract
A novel linker strategy is presented based on a double reductive amination of a dialdehyde to the amine of the amphotericin B mycosamine sugar and the biological activity of a series of conjugates is compared to the native amphotericin B.
摘要
基于二醛与两性霉素B霉菌胺糖的胺基进行双还原胺化反应，提出了一种新型连接策略，并将一系列共轭物的生物活性与天然两性霉素B进行了比较。
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