Krupp L B, Masur D, Schwartz J, Coyle P K, Langenbach L J, Fernquist S K, Jandorf L, Halperin J J
Department of Neurology, State University of New York, Stony Brook 11794.
Arch Neurol. 1991 Nov;48(11):1125-9. doi: 10.1001/archneur.1991.00530230033017.
Lyme borreliosis, a tick-borne multisystem disease, may cause a variety of neurologic complications, including meningoencephalitis and encephalopathy. To evaluate neurobehavioral function following treated Lyme borreliosis, 15 patients with Lyme disease and complaints of persistent cognitive difficulty a mean of 6.7 months following antibiotic treatment underwent neuropsychological evaluation and were compared with 10 healthy controls, matched in aggregate for age and education, who underwent the identical neuropsychological assessment. Compared with controls, patients with Lyme disease exhibited marked impairment on memory tests and particularly on selective reminding measures of memory retrieval. The memory impairment did not correlate with serum or cerebrospinal fluid anti-Borrelia burgdorferi antibody titers and was not explained by magnetic resonance imaging findings or depression. The cause of this encephalopathy is currently unknown; however, indirect effects of systemic infection or other toxic-metabolic factors may be partly responsible.
莱姆病螺旋体病是一种由蜱传播的多系统疾病，可能会引发多种神经并发症，包括脑膜脑炎和脑病。为了评估经治疗的莱姆病螺旋体病后的神经行为功能，15例莱姆病患者在抗生素治疗平均6.7个月后仍有持续认知困难的主诉，接受了神经心理学评估，并与10名年龄和教育程度总体匹配的健康对照者进行了比较，这些对照者接受了相同的神经心理学评估。与对照组相比，莱姆病患者在记忆测试中表现出明显受损，尤其是在记忆提取的选择性提示测量方面。记忆损害与血清或脑脊液抗伯氏疏螺旋体抗体滴度无关，也不能用磁共振成像结果或抑郁来解释。这种脑病的病因目前尚不清楚；然而，全身感染的间接影响或其他毒性代谢因素可能部分起作用。
