Hicks J T, Sullivan J L, Albrecht P
J Immunol. 1977 Oct;119(4):1452-6.
Rhesus monkeys immunosuppressed with horse anti-human thymocyte gamma-globulin (ATG) were infected with measles and simultaneously inoculated with sheep erythrocytes (SRBC), a thymus-dependent antigen, and with pneumococcal polysaccaride type III (SSS-III), a thymus-independent antigen. ATG treatment alone suppressed SRBC antibody production, had no effect on SSS-III antibody production, and effectively eliminated circulating T cells compared to nonsuppressed monkeys. ATG treatment of measles-infected monkeys resulted in delayed virus clearance and delayed antibody production compared to nonsuppressed infected monkeys. After cessation of ATG treatment, measles antibodies and T cells reached normal levels, and measles virus was eliminated. Thus, immune clearance of measles virus is T cell-dependent, but the relative roles of cellular- and humoral-mediated immunity in vivo could not be clearly separated. Also, measles infection was associated with a decreased T cell mitogen responsiveness of circulating lymphocytes but not of lymph node lymphocytes, suggesting an altered circulating pattern of the cells responsible for delayed hypersensitivity. Also, measles infection had no effect on T-dependent antibody production to SRBC.
用马抗人胸腺细胞γ球蛋白（ATG）免疫抑制的恒河猴感染麻疹，并同时接种绵羊红细胞（SRBC，一种胸腺依赖性抗原）和Ⅲ型肺炎球菌多糖（SSS-III，一种非胸腺依赖性抗原）。单独使用ATG治疗可抑制SRBC抗体产生，对SSS-III抗体产生无影响，与未抑制的猴子相比，能有效清除循环T细胞。与未抑制的感染猴子相比，对感染麻疹的猴子进行ATG治疗导致病毒清除延迟和抗体产生延迟。停止ATG治疗后，麻疹抗体和T细胞达到正常水平，麻疹病毒被清除。因此，麻疹病毒的免疫清除依赖于T细胞，但体内细胞介导免疫和体液介导免疫的相对作用无法明确区分。此外，麻疹感染与循环淋巴细胞而非淋巴结淋巴细胞的T细胞有丝分裂原反应性降低有关，提示负责迟发型超敏反应的细胞循环模式发生改变。而且，麻疹感染对针对SRBC的T细胞依赖性抗体产生无影响。
