海生素对艾氏腹水瘤的抑瘤作用：实验研究。

Antitumor effect of the seashell protein Haishengsu on Ehrlich ascites tumor: an experimental study.

机构信息

Liaocheng People's Hospital and Liaocheng Clinical School, Taishan Medical University, 252000 Liaocheng, Shandong, People's Republic of China.

出版信息

J Nat Med. 2009 Oct;63(4):459-62. doi: 10.1007/s11418-009-0346-4. Epub 2009 Jun 18.

DOI:10.1007/s11418-009-0346-4

PMID:19536610

Abstract

The aim of the study was to investigate the in vivo effect of the seashell protein Haishengsu (HSS) on Ehrlich ascites tumor. Mice were inoculated with Ehrlich ascites tumor cells and randomly divided into three HSS groups and a control group. The survival times in the three HSS-treated groups was longer than in the control (P < 0.01) and the increased life span in the high-dose HSS group was greater than in the lower-dose groups (P < 0.05). In comparison with control group, the mice receiving pretreatment of HSS had longer survival times and greater life spans following inoculation of the ascites tumor (P < 0.05). HSS therefore prolongs survival times and increases the life spans of mice bearing Ehrlich ascites tumor. Pretreatment with HSS also diminishes the detrimental effect of Ehrlich ascites tumor on the prognosis of these animals.

摘要

本研究旨在探讨贝壳蛋白海生素（HSS）对艾氏腹水瘤的体内作用。将艾氏腹水瘤细胞接种于小鼠，随机分为三组 HSS 处理组和对照组。与对照组相比，三组 HSS 处理组的存活时间均延长（P<0.01），高剂量 HSS 组的延长生命跨度大于低剂量组（P<0.05）。与对照组相比，HSS 预处理的小鼠在接种腹水瘤后存活时间更长，寿命更长（P<0.05）。因此，HSS 可延长荷艾氏腹水瘤小鼠的存活时间和寿命。HSS 预处理还可减轻艾氏腹水瘤对这些动物预后的不良影响。