Kietzmann Manfred, Bäumer Wolfgang
Institut für Pharmakologie, Toxikologie und Pharmazie, Stiftung Tierärztliche Hochschule Hannover.
Dtsch Tierarztl Wochenschr. 2009 Jun;116(6):204-8.
By treatment of single animals or a live stock a treatment regimen has to be chosen, which guarantees a sufficient concentration of the administered drug in the target tissue. On the other hand, particular care has to be taken to avoid that single animals get a too high, intolerable dose of the administered drug. These elementary requirements must be met by the attending veterinarian.The treatment schedule must be in line with the current phamaceutical law. Some of the most outstanding problems associated with application via feed and water are discussed. Crucial factors apart from practicability are the bioavailability depending on pharmaceutical form and the avoidance of displacements of drugs. Future efforts should focus on the optimization of oral medication.
对于单个动物或家畜的治疗,必须选择一种治疗方案,以确保给药药物在靶组织中达到足够的浓度。另一方面,必须特别注意避免单个动物接受过高的、无法耐受的给药剂量。主治兽医必须满足这些基本要求。治疗方案必须符合现行的药品法规。本文讨论了与通过饲料和水给药相关的一些最突出的问题。除实用性外,关键因素还包括取决于药物剂型的生物利用度以及避免药物置换。未来的工作应集中在口服给药的优化上。