Vermeulen B, De Backer P, Remon J P
Laboratory of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Gent University, Harelbekestraat 72, B-9000 Gent, Belgium.
Adv Drug Deliv Rev. 2002 Oct 4;54(6):795-803. doi: 10.1016/s0169-409x(02)00069-8.
Drugs can be administered to birds either individually or as a flock treatment. For poultry, drinking water and feed medication are preferred, but in the case of serious disease, parenteral administration can be an alternative. For an efficient and safe therapy, data on drug pharmacodynamics and pharmacokinetics are required. Therefore, the gastrointestinal anatomy and physiology of birds, and the elimination of drugs in birds are discussed in this review. In addition, important aspects of drinking water medication, such as water quality, individual water uptake, drinking water system, lighting periods and drug formulations are discussed. Also, some requirements concerning feed medication are mentioned. Finally, parenteral and vaccine administration in the poultry industry are described.
药物可以单独给鸟类使用,也可以进行群体治疗。对于家禽来说,首选饮水给药和饲料给药,但在疾病严重的情况下,可以选择注射给药。为了实现高效、安全的治疗,需要有关药物药效学和药代动力学的数据。因此,本综述讨论了鸟类的胃肠解剖学和生理学,以及鸟类体内药物的消除情况。此外,还讨论了饮水给药的重要方面,如水质量、个体饮水量、饮水系统、光照时间和药物剂型。同时,也提到了饲料给药的一些要求。最后,描述了家禽行业中的注射给药和疫苗接种。