Il'ina E N, Govorun V M
Bioorg Khim. 2009 Mar-Apr;35(2):149-64.
A stable streamlining trend in the field of medical diagnostics by practical adoption of high-tech and knowledge-intensive analytical systems providing for molecular level studies has appeared during the last few decades. An illustrative example of such technologies is mass spectrometry methods for analyzing biomolecules. This review is intended to brief the potential of the state-of-the-art inventory of spectrometry equipment and illustrate the application of mass spectrometry of nucleic acids (DNA and RNA) for solving practical problems related to the analysis of human genomic DNA and clinically significant microorganisms of bacterial and viral natures.
在过去几十年里，通过实际采用能够进行分子水平研究的高科技和知识密集型分析系统，医学诊断领域出现了一种稳定的精简趋势。这类技术的一个典型例子是用于分析生物分子的质谱方法。本综述旨在简要介绍最先进的光谱分析设备的潜力，并举例说明核酸（DNA和RNA）质谱分析在解决与人类基因组DNA分析以及具有临床意义的细菌和病毒性质的微生物分析相关实际问题中的应用。
