Fukuto Jon M, Bianco Christopher L, Chavez Tyler A
Department of Chemistry, Sonoma State University, Rohnert Park, CA 94928, USA.
Free Radic Biol Med. 2009 Nov 1;47(9):1318-24. doi: 10.1016/j.freeradbiomed.2009.06.014. Epub 2009 Jun 17.
Nitroxyl (HNO) has become a nitrogen oxide of significant interest due to its reported biological activity. The actions of HNO in the cardiovascular system appear to make it a good candidate for therapeutic applications for cardiovascular disorders and other potentially important effects have been noted as well. Although the chemistry associated with this activity has not been firmly established, the propensity for HNO to react with thiols and metals are likely mechanisms. Herein, are described the biological activity of HNO and some of the chemistry of HNO that may be responsible for its biological effects.
硝酰（HNO）因其所报道的生物活性而成为一种备受关注的氮氧化物。HNO在心血管系统中的作用似乎使其成为心血管疾病治疗应用的良好候选物，并且还注意到了其他一些潜在的重要作用。尽管与这种活性相关的化学性质尚未完全确定，但HNO与硫醇和金属反应的倾向可能是其作用机制。本文描述了HNO的生物活性以及可能导致其生物效应的一些HNO化学性质。
