嘌呤能P2X(7)受体拮抗剂：化学与生物筛选基础
Purinergic P2X(7) receptor antagonists: Chemistry and fundamentals of biological screening.
作者信息
Gunosewoyo Hendra, Coster Mark J, Bennett Maxwell R, Kassiou Michael
机构信息
School of Chemistry, University of Sydney, NSW 2006, Australia.
出版信息
Bioorg Med Chem. 2009 Jul 15;17(14):4861-5. doi: 10.1016/j.bmc.2009.05.083. Epub 2009 Jun 12.
PMID:19540765
Abstract
The purinergic P2X(7) receptor is a unique member of the ATP-gated P2X family. This receptor has been implicated in numerous diseases and many structurally diverse ligands have been discovered via high throughput screening. This perspective will attempt to highlight some of the most recent key findings in both the biology and chemistry.
摘要
嘌呤能P2X(7)受体是ATP门控P2X家族的一个独特成员。该受体与多种疾病有关，并且通过高通量筛选发现了许多结构多样的配体。本文将试图突出生物学和化学领域的一些最新关键发现。
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