5-氨基水杨酸抑制结直肠癌细胞中的 TGF-β1 信号通路。
5-Aminosalicylic acid inhibits TGF-beta1 signalling in colorectal cancer cells.
机构信息
Department of Gastroenterology-Hepatology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands.
出版信息
Cancer Lett. 2010 Jan 1;287(1):82-90. doi: 10.1016/j.canlet.2009.05.033. Epub 2009 Jun 21.
The transforming growth factor-beta (TGF-beta) pathway is an important pathway in the initiation and progression of colorectal cancer. We aimed to determine the effects of 5-aminosalicylic acid (5-ASA) on TGF-beta signalling in colorectal cancer cells in vitro. 5-ASA inhibited TGF-beta1 signalling in HCT116 cells and colonic fibroblasts, as judged by a TGF-beta-specific reporter gene assay, plasminogen activator inhibitor-1 mRNA and protein levels, fibroblast trans-differentiation, Smad3 phosphorylation and nuclear translocation. We conclude that 5-ASA inhibits TGF-beta1 signalling in colorectal cancer cells, and might be a potent adjuvant therapeutic drug, interfering with aberrant TGF-beta signalling in colorectal cancer.
转化生长因子-β（TGF-β）途径是结直肠癌发生和发展的重要途径。我们旨在确定 5-氨基水杨酸（5-ASA）在体外对结直肠癌细胞 TGF-β信号转导的影响。5-ASA 通过 TGF-β特异性报告基因测定、纤溶酶原激活物抑制剂-1 mRNA 和蛋白水平、成纤维细胞转分化、Smad3 磷酸化和核易位，抑制 HCT116 细胞和结肠成纤维细胞中的 TGF-β1 信号转导。我们的结论是，5-ASA 抑制结直肠癌细胞中的 TGF-β1 信号转导，并且可能是一种有效的辅助治疗药物，通过干扰结直肠癌中异常的 TGF-β 信号转导。
Zotero 插件