Hu Zhizhong, Liu Yitong, Liu Meiqi, Zhang Yang, Wang Chengkun
Cancer Research Institute, Medical School, University of South China, Hengyang, Hunan 421001, P.R. China.
Oncol Lett. 2023 Feb 2;25(3):107. doi: 10.3892/ol.2023.13693. eCollection 2023 Mar.
Long non-coding RNAs (lncRNAs) are a class of RNAs that are >200 nucleotides in length that do not have the ability to be translated into protein but are associated with numerous diseases, including cancer. The involvement of lncRNAs in the signalling of certain signalling pathways can promote tumour progression; these pathways include the transforming growth factor (TGF)-β signalling pathway, which is related to tumour development. The expression of lncRNAs in various tumour tissues is specific, and their interaction with the TGF-β signalling pathway indicates that they may serve as new tumour markers and therapeutic targets. The present review summarized the role of TGF-β pathway-associated lncRNAs in regulating tumorigenesis in different types of cancer and their effects on the TGF-β signalling pathway.
长链非编码RNA（lncRNAs）是一类长度大于200个核苷酸的RNA，它们没有能力被翻译成蛋白质，但与包括癌症在内的多种疾病相关。lncRNAs参与某些信号通路的信号传导可促进肿瘤进展；这些通路包括与肿瘤发展相关的转化生长因子（TGF）-β信号通路。lncRNAs在各种肿瘤组织中的表达具有特异性，它们与TGF-β信号通路的相互作用表明它们可能作为新的肿瘤标志物和治疗靶点。本综述总结了与TGF-β通路相关的lncRNAs在调节不同类型癌症肿瘤发生中的作用及其对TGF-β信号通路的影响。
