Hewlett E L, Manclark C R, Wolff J
J Infect Dis. 1977 Aug;136 Suppl:S216-9. doi: 10.1093/infdis/136.supplement.s216.
Brodetella pertussis organisms have a large amount of extracytoplasmic adenyl cyclase, part of which is found in the supernatant culture medium during exponential growth. The enzyme differs from previously studied bacterial adenyl cyclases in biochemical characteristics as well as in location. Several commercial pertussis vaccines were found to contain adenyl cyclase activity; this activity is probably due to the extracytoplasmic enzyme associated with and released from the whole cells in the vaccine.
百日咳博德特氏菌含有大量胞外腺苷酸环化酶，在指数生长期，部分该酶存在于上清培养基中。这种酶在生化特性和位置上与先前研究的细菌腺苷酸环化酶不同。发现几种市售百日咳疫苗含有腺苷酸环化酶活性；这种活性可能归因于与疫苗中全细胞相关并从全细胞释放的胞外酶。
