Gupta Amitabh, Lang Anthony E
Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada.
Curr Opin Neurol. 2009 Aug;22(4):430-6. doi: 10.1097/WCO.0b013e32832dc169.
This review summarizes the progress made in the area of psychogenic movement disorders (PMDs) over the past 2 years, and a simplified classification of diagnostic certainty is proposed that incorporates electrophysiological assessment.
Functional magnetic resonance imaging studies have demonstrated altered blood flow in conversion disorders that may reflect changes in synaptic activity. Electrophysiological testing shows limitations in distinguishing between psychogenic and organic propriospinal myoclonus and dystonia. Recent evidence cautions against the uncritical acceptance of all cases of posttraumatic myoclonus and 'jumpy stump' as being organic in nature. 'Essential palatal tremor' is recognized as a rather heterogeneous group of tremors that includes psychogenic tremor. Two recent studies evaluating the long-term prognosis of psychogenic tremor differ in the degree of unfavorable outcome. Different groups of PMDs might have distinctive gait characteristics with prognostic, diagnostic, or therapeutic value. Two recent reviews provide comprehensive information on the understudied area of PMDs in children.
The diagnosis of PMDs should not be regarded as a diagnosis of exclusion. Careful clinical assessment is critical, and imaging or electrophysiological studies may provide important insights and confirmation of the diagnosis though some cases remain challenging and current assessments fail to provide needed clarification. Treatment is often delayed, contributing to a largely unfavorable long-term outcome. Well designed randomized control trials that validate and compare therapeutic options are urgently required.
本综述总结了过去两年心理性运动障碍(PMDs)领域取得的进展,并提出了一种纳入电生理评估的简化诊断确定性分类方法。
功能磁共振成像研究表明,转换障碍中血流改变可能反映突触活动的变化。电生理测试在区分心理性和器质性脊髓固有肌阵挛及肌张力障碍方面存在局限性。最近的证据提醒不要不加批判地接受所有创伤后肌阵挛和“跳跃性残端”病例为器质性病变。“原发性腭震颤”被认为是一组相当异质性的震颤,包括心理性震颤。最近两项评估心理性震颤长期预后的研究在不良结局程度上存在差异。不同类型的PMDs可能具有独特的步态特征,具有预后、诊断或治疗价值。最近的两篇综述提供了关于儿童PMDs研究较少领域的全面信息。
PMDs的诊断不应被视为排除性诊断。仔细的临床评估至关重要,影像学或电生理研究可能提供重要的见解并证实诊断,尽管有些病例仍然具有挑战性,目前的评估未能提供所需的澄清。治疗往往延迟,导致长期结局大多不佳。迫切需要设计良好的随机对照试验来验证和比较治疗方案。