髓过氧化物酶基因及其对瑞典人群心肌梗死的影响：-129A等位基因在女性中的保护作用。

The myeloperoxidase gene and its influence on myocardial infarction in a Swedish population: protective role of the -129A allele in women.

作者信息

Zotova Elena, Lyrenäs Louise, de Faire Ulf, Morgenstern Ralf, Gigante Bruna, Bennet Anna M

机构信息

of Biochemical Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm S-171 77, Sweden.

出版信息

Coron Artery Dis. 2009 Aug;20(5):322-6. doi: 10.1097/MCA.0b013e32832da06d.

DOI:10.1097/MCA.0b013e32832da06d

PMID:19543083

Abstract

OBJECTIVE

The aim of this study is to investigate the potential role of functional myeloperoxidase (MPO) promoter polymorphisms in the occurrence of myocardial infarction (MI) in the Stockholm Heart Epidemiology Program.

METHODS AND RESULTS

Two MPO promoter polymorphisms, -129G/A and -463G/A, were genotyped in the Stockholm Heart Epidemiology Program population (n = 2774). The -129A allele was associated with a lower risk of MI in women [odds ratio (OR) (95% confidence interval): 0.65 (0.43-0.98), P = 0.03] but not in men [OR: 1.12 (0.86-1.47), P = 0.38]. When women were stratified by age and hormone replacement therapy, the protective effect of the -129A allele was only evident in women younger than 55 years or not receiving hormone replacement therapy. In these two groups, OR (95% confidence interval) for carriers of the -129A allele were 0.34 (0.12-0.92) (P = 0.03) and 0.51 (0.32-0.81) (P = 0.004), respectively. For the -463G/A polymorphism, no associations to MI risk were observed either in women or in men.

CONCLUSION

The A allele of the MPO -129G/A promoter polymorphism is associated with a reduced MI risk in women.

摘要

目的

本研究旨在调查功能性髓过氧化物酶（MPO）启动子多态性在斯德哥尔摩心脏流行病学项目心肌梗死（MI）发生中的潜在作用。

方法与结果

在斯德哥尔摩心脏流行病学项目人群（n = 2774）中对两种MPO启动子多态性，即-129G/A和-463G/A进行基因分型。-129A等位基因与女性MI风险降低相关[比值比（OR）（95%置信区间）：0.65（0.43 - 0.98），P = 0.03]，但与男性无关[OR：1.12（0.86 - 1.47），P = ；当按年龄和激素替代疗法对女性进行分层时，-129A等位基因的保护作用仅在55岁以下或未接受激素替代疗法的女性中明显。在这两组中，-129A等位基因携带者的OR（95%置信区间）分别为0.34（0.12 - 0.92）（P = 0.03）和0.51（0.（P = 0.004）。对于-463G/A多态性，在女性或男性中均未观察到与MI风险的关联。