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PRISMA合并髓过氧化物酶-463G/A基因多态性与冠状动脉疾病：对4744名受试者的荟萃分析

PRISMA-combined Myeloperoxidase -463G/A gene polymorphism and coronary artery disease: A meta-analysis of 4744 subjects.

作者信息

Li Yan-Yan, Wang Hui, Qian Jin, Kim Hyun Jun, Wu Jing-Jing, Wang Lian-Sheng, Zhou Chuan-Wei, Yang Zhi-Jian, Lu Xin-Zheng

机构信息

Department of Geriatrics Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China Department of Physiology, University of Cincinnati, Cincinnati, OH Department of Nephrology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

出版信息

Medicine (Baltimore). 2017 Mar;96(12):e6461. doi: 10.1097/MD.0000000000006461.

DOI:10.1097/MD.0000000000006461
PMID:28328864
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5371501/
Abstract

BACKGROUND

Myeloperoxidase (MPO) -463G/A gene polymorphism may be associated with an increased risk of developing coronary artery disease (CAD). Studies on the subject, however, do not provide a clear consensus. This meta-analysis was performed to explore the relationship between MPO gene -463G/A polymorphism and CAD risk.

METHODS

This meta-analysis combines data from 4744 subjects from 9 independent studies. By using fixed or random effect models, the pooled odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were assessed.

RESULTS

Our analysis found a significant association between MPO gene -463G/A polymorphism and CAD in the whole population under all genetic models: allelic (OR: 0.68, 95% CI: 0.54-0.85, P = 0.0009), recessive (OR: 0.41, 95% CI: 0.22-0.76, P = 0.005), dominant (OR: 0.682, 95% CI: 0.534-0.871, P = 0.002), homozygous (OR: 0.36, 95% CI: 0.16-0.79, P = 0.01), heterozygous genetic model (OR: 0.832, 95% CI: 0.733-0.945, P = 0.004), and additive (OR: 0.64, 95% CI: 0.46-0.90, P = 0.01), especially in the Chinese subgroup (P < 0.05). On the contrary, we found no such relationship in the non-Chinese subgroup (P > 0.05).

CONCLUSION

The MPO gene -463G/A polymorphism is associated with CAD risk, especially within the Chinese population. The A allele of MPO gene -463G/A polymorphism might protect the people from suffering the CAD risk.

摘要

背景

髓过氧化物酶（MPO）-463G/A基因多态性可能与冠状动脉疾病（CAD）发生风险增加有关。然而，关于该主题的研究并未达成明确共识。进行此项荟萃分析以探讨MPO基因-463G/A多态性与CAD风险之间的关系。

方法

该荟萃分析合并了来自9项独立研究的4744名受试者的数据。通过使用固定或随机效应模型，评估汇总比值比（OR）及其相应的95%置信区间（CI）。

结果

我们的分析发现在所有遗传模型下，MPO基因-463G/A多态性与整个人群的CAD之间存在显著关联：等位基因（OR：0.68，95%CI：0.54 - 0.85，P = 0.0009）、隐性（OR：0.41，95%CI：0.22 - 0.76，P = 0.005）、显性（OR：0.682，95%CI：0.534 - 0.871，P = 0.002）、纯合子（OR：0.36，95%CI：0.16 - 0.79，P = 0.01）、杂合子遗传模型（OR：0.832，95%CI：0.733 - 0.945，P = 0.004）以及相加模型（OR：0.64，95%CI：0.46 - 0.90，P = 0.01），尤其是在中国亚组中（P < 0.05）。相反，在非中国亚组中未发现这种关系（P > 0.05）。

结论

MPO基因-463G/A多态性与CAD风险相关，尤其是在中国人群中。MPO基因-463G/A多态性的A等位基因可能使人们免受CAD风险。

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