根治性治疗后生化前列腺癌复发的双示踪剂 11C-胆碱和 FDG-PET 诊断。
Dual tracer 11C-choline and FDG-PET in the diagnosis of biochemical prostate cancer relapse after radical treatment.
机构信息
Nuclear Medicine Department, Clínica Universitaria, Universidad de Navarra, Avenida Pío XII 36, Pamplona, Spain.
出版信息
Mol Imaging Biol. 2010 Apr;12(2):210-7. doi: 10.1007/s11307-009-0243-y. Epub 2009 Jun 19.
PURPOSE
The purpose of this study was to evaluate a dual tracer 2-deoxy-2-[F-18]fluoro-D: -glucose (FDG) and (11)C-choline positron emission tomography (PET) protocol in the detection of biochemical prostate cancer relapse.
PROCEDURES
Seventy-three patients (median Prostate Specific Antigen (PSA) Test value 2.7 ng/ml (1.1-5.4)) after radical treatment. PET scans were performed by means of a ECAT-Exact HR+ in the first 18 patients and in a PET/computed tomography Biograph II in the remaining 55 patients.
RESULTS
The sensitivity of (11)C-choline and FDG was 60.6% and 31%. In PSA levels over 1.9 ng/ml, sensitivity increased to 80% and 40%, respectively. In the group receiving adjuvant hormone therapy, the diagnostic yields were 71.2% and 43%, respectively. While (11)C-choline-PET could not differentiate well and poorly differentiated Gleason score patients, FDG-PET results were almost significant (p = 0.058).
CONCLUSIONS
A PSA value higher than 1.9 ng/ml determines a significant increase in the diagnostic yield. Adjuvant hormonotherapy has no influence on the PET results. FDG has a better correlation with the Gleason score than (11)C-choline.
目的
本研究旨在评估双示踪剂 2-脱氧-2-[F-18]氟-D: -葡萄糖（FDG）和（11）C-胆碱正电子发射断层扫描（PET）方案在检测生化前列腺癌复发中的作用。
方法
73 例患者（中位前列腺特异性抗原（PSA）检测值为 2.7ng/ml（1.1-5.4）），接受根治性治疗后。前 18 例患者采用 ECAT-Exact HR+进行 PET 扫描，其余 55 例患者采用 PET/CT Biograph II 进行扫描。
结果
（11）C-胆碱和 FDG 的灵敏度分别为 60.6%和 31%。在 PSA 水平超过 1.9ng/ml 时，灵敏度分别增加到 80%和 40%。在接受辅助激素治疗的患者中，诊断率分别为 71.2%和 43%。虽然（11）C-胆碱-PET 不能很好地区分高分化和低分化 Gleason 评分患者，但 FDG-PET 结果几乎有统计学意义（p=0.058）。
结论
PSA 值高于 1.9ng/ml 可显著提高诊断率。辅助激素治疗对 PET 结果无影响。FDG 与 Gleason 评分的相关性优于（11）C-胆碱。
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