Nuclear Medicine Department, Clínica Universitaria, Universidad de Navarra, Avenida Pío XII 36, Pamplona, Spain.
Mol Imaging Biol. 2010 Apr;12(2):210-7. doi: 10.1007/s11307-009-0243-y. Epub 2009 Jun 19.
The purpose of this study was to evaluate a dual tracer 2-deoxy-2-[F-18]fluoro-D: -glucose (FDG) and (11)C-choline positron emission tomography (PET) protocol in the detection of biochemical prostate cancer relapse.
Seventy-three patients (median Prostate Specific Antigen (PSA) Test value 2.7 ng/ml (1.1-5.4)) after radical treatment. PET scans were performed by means of a ECAT-Exact HR+ in the first 18 patients and in a PET/computed tomography Biograph II in the remaining 55 patients.
The sensitivity of (11)C-choline and FDG was 60.6% and 31%. In PSA levels over 1.9 ng/ml, sensitivity increased to 80% and 40%, respectively. In the group receiving adjuvant hormone therapy, the diagnostic yields were 71.2% and 43%, respectively. While (11)C-choline-PET could not differentiate well and poorly differentiated Gleason score patients, FDG-PET results were almost significant (p = 0.058).
A PSA value higher than 1.9 ng/ml determines a significant increase in the diagnostic yield. Adjuvant hormonotherapy has no influence on the PET results. FDG has a better correlation with the Gleason score than (11)C-choline.
本研究旨在评估双示踪剂 2-脱氧-2-[F-18]氟-D: -葡萄糖（FDG）和（11）C-胆碱正电子发射断层扫描（PET）方案在检测生化前列腺癌复发中的作用。
73 例患者（中位前列腺特异性抗原（PSA）检测值为 2.7ng/ml（1.1-5.4）），接受根治性治疗后。前 18 例患者采用 ECAT-Exact HR+进行 PET 扫描，其余 55 例患者采用 PET/CT Biograph II 进行扫描。
（11）C-胆碱和 FDG 的灵敏度分别为 60.6%和 31%。在 PSA 水平超过 1.9ng/ml 时，灵敏度分别增加到 80%和 40%。在接受辅助激素治疗的患者中，诊断率分别为 71.2%和 43%。虽然（11）C-胆碱-PET 不能很好地区分高分化和低分化 Gleason 评分患者，但 FDG-PET 结果几乎有统计学意义（p=0.058）。
PSA 值高于 1.9ng/ml 可显著提高诊断率。辅助激素治疗对 PET 结果无影响。FDG 与 Gleason 评分的相关性优于（11）C-胆碱。
