Skyschally Andreas, van Caster Patrick, Iliodromitis Efstathios K, Schulz Rainer, Kremastinos Dimitrios T, Heusch Gerd
Institut für Pathophysiologie, Universitätsklinikum Essen, Essen, Germany.
Basic Res Cardiol. 2009 Sep;104(5):469-83. doi: 10.1007/s00395-009-0040-4. Epub 2009 Jun 19.
Ischemic postconditioning, a simple mechanical maneuver at the onset of reperfusion, reduces infarct size after ischemia/reperfusion. After its first description in 2003 by Zhao et al. numerous experimental studies have investigated this protective phenomenon. Whereas the underlying mechanisms and signal transduction are not yet understood in detail, infarct size reduction by ischemic postconditioning was confirmed in all species tested so far, including man. We have now reviewed the literature with focus on experimental models and protocols to better understand the determinants of protection by ischemic postconditioning or lack of it. Only studies with infarct size as unequivocal endpoint were considered. In all species and models, the duration of index ischemia and the protective protocol algorithm impact on the outcome of ischemic postconditioning, and gender, age, and myocardial temperature contribute.
缺血后处理是一种在再灌注开始时进行的简单机械操作，可减小缺血/再灌注后的梗死面积。自2003年赵等人首次描述该现象以来，众多实验研究对这一保护现象进行了探究。尽管其潜在机制和信号转导尚未完全明确，但迄今为止，包括人类在内的所有受试物种均证实了缺血后处理可减小梗死面积。我们现在回顾了相关文献，重点关注实验模型和方案，以更好地理解缺血后处理发挥保护作用或未能发挥保护作用的决定因素。仅纳入了以梗死面积作为明确终点的研究。在所有物种和模型中，初始缺血的持续时间以及保护方案算法会影响缺血后处理的结果，此外，性别、年龄和心肌温度也会产生影响。
