早期经历以及接触催产素和加压素所产生的后果存在性别差异。
Consequences of early experiences and exposure to oxytocin and vasopressin are sexually dimorphic.
作者信息
Carter C Sue, Boone Ericka M, Pournajafi-Nazarloo Hossein, Bales Karen L
机构信息
Department of Psychiatry, Brain Body Center, University of Illinois at Chicago, Chicago, Ill. 60612, USA.
出版信息
Dev Neurosci. 2009;31(4):332-41. doi: 10.1159/000216544. Epub 2009 Jun 17.
Abstract
In the socially monogamous prairie vole, we have observed that small changes in early handling, as well as early hormonal manipulations can have long-lasting and sexually dimorphic effects on behavior. These changes may be mediated in part by changes in parental interactions with their young, acting on systems that rely on oxytocin (OT) and arginine vasopressin (AVP). Knowledge of both endogenous and exogenous influences on systems that rely on OT and AVP may be helpful in understanding sexually dimorphic developmental disorders, such as autism, that are characterized by increased anxiety and deficits in social behavior.
摘要
在实行社会一夫一妻制的草原田鼠中，我们观察到早期处理方式的微小变化以及早期激素操纵会对行为产生持久且具有性别差异的影响。这些变化可能部分是由亲代与幼崽互动的改变所介导的，作用于依赖催产素（OT）和精氨酸加压素（AVP）的系统。了解内源性和外源性对依赖OT和AVP系统的影响，可能有助于理解以焦虑增加和社交行为缺陷为特征的性别差异发育障碍，如自闭症。
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