da Silva Rodrigo Costa, Langoni Helio
Department of Veterinary Hygiene and Animal Science, College of Veterinary Medicine and Animal Science, São Paulo State University, Campus of Botucatu, Botucatu, São Paulo, Brazil.
Parasitol Res. 2009 Oct;105(4):893-8. doi: 10.1007/s00436-009-1526-6. Epub 2009 Jun 23.
Toxoplasma gondii is an obligate intracellular parasite that causes different lesions in men and other warm-blooded animals. Humoral and cellular immune response of the host against the parasite keeps the protozoan in a latent stage, and clinical disease ensues when immunological response is compromised. Brain parasitism benefits the parasite causing behavioral changes in the host, not only in animals but also in humans. Schizophrenia and epilepsy are two neurological disorders that have recently been reported to affect humans coinfected with T. gondii. Further studies based on host-parasite interaction in several wild or domestic warm-blooded species are still necessary in order to better understand parasitism and behavioral changes caused by T. gondii.
刚地弓形虫是一种专性细胞内寄生虫，可在人类和其他温血动物体内引发不同病变。宿主针对该寄生虫的体液免疫和细胞免疫反应可使这种原生动物处于潜伏阶段，而当免疫反应受损时就会引发临床疾病。脑部寄生对寄生虫有利，会导致宿主出现行为变化，不仅在动物中如此，在人类中也是如此。精神分裂症和癫痫是最近报道的两种会影响刚地弓形虫合并感染人类的神经疾病。为了更好地理解刚地弓形虫引起的寄生现象和行为变化，仍有必要基于几种野生或家养温血动物物种的宿主-寄生虫相互作用开展进一步研究。
