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卵母细胞捐赠周期中卵泡期和黄体期子宫内膜厚度、回声模式与妊娠结局

Follicular and luteal phase endometrial thickness and echogenic pattern and pregnancy outcome in oocyte donation cycles.

作者信息

Barker Matthew A, Boehnlein Lynn M, Kovacs Peter, Lindheim Steven R

机构信息

Department of Obstetrics and Gynecology, Good Samaritan Hospital, 3219 Clifton Ave. Suite #100, Cincinnati, OH 45220, USA.

出版信息

J Assist Reprod Genet. 2009 May;26(5):243-9. doi: 10.1007/s10815-009-9312-z. Epub 2009 Jun 23.

DOI:10.1007/s10815-009-9312-z
PMID:19548081
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2719070/
Abstract

PURPOSE

To study the effect of endometrial thickness (ET) and echogenic pattern (EP) in oocyte donation cycles upon pregnancy outcomes.

METHODS

Seventy-nine cycles resulting in blastocyst embryo transfer were evaluated. Donors underwent ovarian hyperstimulation using rFSH and GnRH-antagonist. Recipients were synchronized to donors using GnRH-agonist down-regulation followed by fixed dose of estrogen (E2) and progesterone (P4) following hCG. Transvaginal ultrasound (US) obtained ET and EP 10-11 days after initiation of E2 and on day of embryo transfer. Primary outcome was ET and EP in pregnant and non-pregnant cycles. Stimulation and embryology data was analyzed in donors to assess differences prior to transfer.

RESULTS

Fifty-nine cycles resulted in clinical pregnancy. No differences were observed in pregnant vs. non-pregnant cycles in proliferative or secretory ET and EP. Similar baseline and stimulation characteristics were found in pregnant and non-pregnant cycles. Regression analysis showed end thickness were not predictive of pregnancy outcomes.

CONCLUSIONS

Endometrial characteristics in recipients prior to and following progesterone were not predictive of pregnancy outcomes.

摘要

目的

研究卵母细胞捐赠周期中子宫内膜厚度（ET）和回声模式（EP）对妊娠结局的影响。

方法

对79个导致囊胚胚胎移植的周期进行评估。供体使用重组促卵泡激素（rFSH）和促性腺激素释放激素拮抗剂（GnRH-antagonist）进行卵巢超刺激。受体使用GnRH激动剂下调，随后在人绒毛膜促性腺激素（hCG）后给予固定剂量的雌激素（E2）和孕激素（P4），使其与供体同步。在开始使用E2后10 - 11天以及胚胎移植当天，通过经阴道超声（US）测量ET和EP。主要结局是妊娠周期和未妊娠周期中的ET和EP。对供体的刺激和胚胎学数据进行分析，以评估移植前的差异。

结果

59个周期实现了临床妊娠。在增殖期或分泌期的ET和EP方面，妊娠周期与未妊娠周期之间未观察到差异。在妊娠周期和未妊娠周期中发现了相似的基线和刺激特征。回归分析表明子宫内膜厚度不能预测妊娠结局。

结论

孕激素使用前后受体的子宫内膜特征不能预测妊娠结局。

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