Loenarz Christoph, Schofield Christopher J
Chemistry Research Laboratory and The Oxford Centre for Integrative Systems Biology, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK.
Chem Biol. 2009 Jun 26;16(6):580-3. doi: 10.1016/j.chembiol.2009.06.002.
Recent reports identify the oxygenase catalyzed production of 5-hydroxymethylcytosine as a modification to mammalian DNA (Kriaucionis and Heintz, 2009; Tahiliani et al., 2009). This discovery has potential far-reaching implications for epigenetic regulation and will stimulate efforts to identify new nucleic acid modifications.
近期报告指出，加氧酶催化产生的5-羟甲基胞嘧啶是哺乳动物DNA的一种修饰（克里奥基奥尼斯和海因茨，2009年；塔希利亚尼等人，2009年）。这一发现对表观遗传调控具有潜在的深远影响，并将推动人们努力识别新的核酸修饰。
