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肺侵袭性炎性肌纤维母细胞瘤

Invasive inflammatory myofibroblastic tumor of the lung.

作者信息

van den Heuvel Daniel A, Keijsers Ruth G, van Es Hendrik W, Bootsma Gerben P, de Bruin Peter C, Schramel Franz M, van Heesewijk Johannes P

机构信息

Department of Radiology, St Antonius Hospital, Nieuwegein, The Netherlands.

出版信息

J Thorac Oncol. 2009 Jul;4(7):923-6. doi: 10.1097/JTO.0b013e3181a76e28.

Abstract

Inflammatory myofibroblastic tumor (IMT) of the lung is a rare tumor but it should be considered when dealing with primary lung tumors in children, adolescents, and nonsmoking adults. It is, from a pathologic point of view, a benign tumor composed of a spindle cell proliferation and inflammatory cells. Its clinical behavior, however, is variable with a benign evolution at one, and a malignant evolution with recurrent and metastatic disease at the other end of the spectrum. Diagnosis is very difficult and often only possible after resection of the tumor. We present a case of pulmonary IMT in a 15-year-old male with malignant features on radiographic and F-Fluoro-deoxyglucose positron emission tomography imaging. Pathogenesis, pathology findings, clinical behavior, and imaging of pulmonary IMT are briefly discussed.

摘要

肺炎性肌纤维母细胞瘤(IMT)是一种罕见肿瘤,但在处理儿童、青少年及不吸烟成年人的原发性肺肿瘤时应予以考虑。从病理学角度来看,它是一种由梭形细胞增殖和炎症细胞组成的良性肿瘤。然而,其临床行为具有多样性,一端是良性演变,另一端则是伴有复发和转移性疾病的恶性演变。诊断非常困难,通常只有在肿瘤切除后才有可能确诊。我们报告一例15岁男性的肺IMT病例,其在影像学和F-氟脱氧葡萄糖正电子发射断层扫描成像上具有恶性特征。本文简要讨论了肺IMT的发病机制、病理表现、临床行为及影像学特征。

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