van den Heuvel Daniel A, Keijsers Ruth G, van Es Hendrik W, Bootsma Gerben P, de Bruin Peter C, Schramel Franz M, van Heesewijk Johannes P
Department of Radiology, St Antonius Hospital, Nieuwegein, The Netherlands.
J Thorac Oncol. 2009 Jul;4(7):923-6. doi: 10.1097/JTO.0b013e3181a76e28.
Inflammatory myofibroblastic tumor (IMT) of the lung is a rare tumor but it should be considered when dealing with primary lung tumors in children, adolescents, and nonsmoking adults. It is, from a pathologic point of view, a benign tumor composed of a spindle cell proliferation and inflammatory cells. Its clinical behavior, however, is variable with a benign evolution at one, and a malignant evolution with recurrent and metastatic disease at the other end of the spectrum. Diagnosis is very difficult and often only possible after resection of the tumor. We present a case of pulmonary IMT in a 15-year-old male with malignant features on radiographic and F-Fluoro-deoxyglucose positron emission tomography imaging. Pathogenesis, pathology findings, clinical behavior, and imaging of pulmonary IMT are briefly discussed.
肺炎性肌纤维母细胞瘤(IMT)是一种罕见肿瘤,但在处理儿童、青少年及不吸烟成年人的原发性肺肿瘤时应予以考虑。从病理学角度来看,它是一种由梭形细胞增殖和炎症细胞组成的良性肿瘤。然而,其临床行为具有多样性,一端是良性演变,另一端则是伴有复发和转移性疾病的恶性演变。诊断非常困难,通常只有在肿瘤切除后才有可能确诊。我们报告一例15岁男性的肺IMT病例,其在影像学和F-氟脱氧葡萄糖正电子发射断层扫描成像上具有恶性特征。本文简要讨论了肺IMT的发病机制、病理表现、临床行为及影像学特征。