诱导型精氨酸酶导致巨噬细胞对体外细胞毒性反应的抑制。
Suppression of in vitro cytotoxic response by macrophages due to induced arginase.
作者信息
Kung J T, Brooks S B, Jakway J P, Leonard L L, Talmage D W
出版信息
J Exp Med. 1977 Sep 1;146(3):665-72. doi: 10.1084/jem.146.3.665.
Abstract
Arginine was found to be completely depleted from cell-free supernates of mixed leukocyte cultures suppressed by the addition of excess macrophages. Partial reversal of macrophage-mediated suppression was accomplished by daily addition of a cocktail containing arginine and nonamino acid nutrients. Complete reversal of the suppression was accomplished by the addition of arginine and glucose to the medium and the nonadherent cells after their separation from the adherent macrophages. A marked increase in the enzyme arginase was found in macrophages that had been cultured 24 h in vitro in Eagle's minimum essential medium plus 10% fetal calf serum, in peritoneal cells activated by prior injection of thioglycollate, and in one spleen activated by a graft vs. host reaction.
摘要
研究发现，在添加过量巨噬细胞而受到抑制的混合白细胞培养物的无细胞上清液中，精氨酸完全耗尽。通过每日添加含有精氨酸和非氨基酸营养素的混合物，可部分逆转巨噬细胞介导的抑制作用。将精氨酸和葡萄糖添加到培养基中，并在非贴壁细胞与贴壁巨噬细胞分离后添加，可完全逆转抑制作用。在含有10%胎牛血清的伊格尔最低限度基本培养基中体外培养24小时的巨噬细胞、预先注射巯基乙酸而激活的腹腔细胞以及因移植物抗宿主反应而激活的一个脾脏中，发现精氨酸酶显著增加。
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